Obsessive master thief, Neil McCauley leads a top-notch crew on various daring heists throughout Los Angeles while determined detective, Vincent Hanna pursues him without rest. Each man recognizes and respects the ability and the dedication of the other even though they are aware their cat-and-mouse game may end in violence.
Some of Sin City's most hard-boiled citizens cross paths with a few of its more reviled inhabitants.
Léon, the top hit man in New York, has earned a rep as an effective "cleaner". But when his next-door neighbors are wiped out by a loose-cannon DEA agent, he becomes the unwilling custodian of 12-year-old Mathilda. Before long, Mathilda's thoughts turn to revenge, and she considers following in Léon's footsteps.
An ex-tennis pro carries out a plot to have his wife murdered after discovering she is having an affair, and assumes she will soon leave him for the other man anyway. When things go wrong, he improvises a new plan—to frame her for murder instead.
John Anderton is a top 'Precrime' cop in the late-21st century, when technology can predict crimes before they're committed. But Anderton becomes the quarry when another investigator targets him for a murder charge.
Baker Dill is a fishing boat captain leading tours off a tranquil, tropical enclave called Plymouth Island. His quiet life is shattered, however, when his ex-wife Karen tracks him down with a desperate plea for help.
Blonde Betty Elms has only just arrived in Hollywood to become a movie star when she meets an enigmatic brunette with amnesia. Meanwhile, as the two set off to solve the second woman's identity, filmmaker Adam Kesher runs into ominous trouble while casting his latest project.
Homicide detective John Hobbes witnesses the execution of serial killer Edgar Reese. Soon after the execution the killings start again, and they are very similar to Reese's style.